Whether on personal health, politics, or climate change, we are constantly bombarded with more numerous 'breaking news' articles than we have time for. In such an environment, how can we tell which to read, or which is even true. Science of the Earth, Climate and Energy helps readers understand major issues that affect us individually and the world as a whole. In language that a non-scientist can follow easily, the book first explains the general principles of science, its nature and (...) how it works, with a certain degree of emphasis on the meaning of the words "uncertainty" and "fact, before it goes into the related topics of the earth, its climate and energy sources at a level that does not require a background in science. Finally, the book addresses what individuals and societies can do to mitigate problems associated with both climate change and limited resources. (shrink)

In his commentary, Oaksford makes two main claims: (1) that the externalisation method used by Green, Over, and Pyne (1997) enforces the correlation observed between probability estimates and selection, and (2) that these estimates support the prediction of a downward revision of P(p) when P(p) > P(q). In this reply, we rebut claim 1 by describing the instructions more comprehensively, and claim 2 by reiterating the importance of making certain theoretical distinctions which Oaksford does not make. Our interest is (...) the psychological process of reaching decision: externalisation methods provide a means of exploring this process and of assessing the value of Bayesian approaches. (shrink)

Mesoscale modeling is often considered merely as a practical strategy used when information on lower-scale details is lacking, or when there is a need to make models cognitively or computationally tractable. Without dismissing the importance of practical constraints for modeling choices, we argue that mesoscale models should not just be considered as abbreviations or placeholders for more “complete” models. Because many systems exhibit different behaviors at various spatial and temporal scales, bottom-up approaches are almost always doomed to fail. Mesoscale models (...) capture aspects of multi-scale systems that cannot be parameterized by simple averaging of lower-scale details. To understand the behavior of multi-scale systems, it is essential to identify mesoscale parameters that “code for” lower-scale details in a way that relate phenomena intermediate between microscopic and macroscopic features. We illustrate this point using examples of modeling of multi-scale systems in materials science and biology, where identification of material parameters such as stiffness or strain is a central step. The examples illustrate important aspects of a so-called “middle-out” modeling strategy. Rather than attempting to model the system bottom-up, one starts at intermediate scales where systems exhibit behaviors distinct from those at the atomic and continuum scales. One then seeks to upscale and downscale to gain a more complete understanding of the multi-scale system. The cases highlight how parameterization of lower-scale details not only enables tractable modeling but is also central to understanding functional and organizational features of multi-scale systems. (shrink)

Precision medicine and molecular systems medicine (MSM) are highly utilized and successful approaches to improve understanding, diagnosis, and treatment of many diseases from bench-to-bedside. Especially in the COVID-19 pandemic, molecular techniques and biotechnological innovation have proven to be of utmost importance for rapid developments in disease diagnostics and treatment, including DNA and RNA sequencing technology, treatment with drugs and natural products and vaccine development. The COVID-19 crisis, however, has also demonstrated the need for systemic thinking and transdisciplinarity and the limits (...) of MSM: the neglect of the bio-psycho-social systemic nature of humans and their context as the object of individual therapeutic and population-oriented interventions. COVID-19 illustrates how a medical problem requires a transdisciplinary approach in epidemiology, pathology, internal medicine, public health, environmental medicine, and socio-economic modeling. Regarding the need for conceptual integration of these different kinds of knowledge we suggest the application of general system theory (GST). This approach endorses an organism-centered view on health and disease, which according to Ludwig von Bertalanffy who was the founder of GST, we call Organismal Systems Medicine (OSM). We argue that systems science offers wider applications in the field of pathology and can contribute to an integrative systems medicine by (i) integration of evidence across functional and structural differentially scaled subsystems, (ii) conceptualization of complex multilevel systems, and (iii) suggesting mechanisms and non-linear relationships underlying the observed phenomena. We underline these points with a proposal on multi-level systems pathology including neurophysiology, endocrinology, immune system, genetics, and general metabolism. An integration of these areas is necessary to understand excess mortality rates and polypharmacological treatments. In the pandemic era this multi-level systems pathology is most important to assess potential vaccines, their effectiveness, short-, and long-time adverse effects. We further argue that these conceptual frameworks are not only valid in the COVID-19 era but also important to be integrated in a medicinal curriculum. (shrink)

Originally presented as author's thesis (Ph. D.--Madurai Kamaraj University).

Are the words that a novelist uses adequate to his or her elusive subject&—the human condition? Are they pertinent, accurate, invariably fair, unflinchingly honest? Or do the novelist's words execute essentially formal maneuvers, engaging our interest through their patterns rather than their reach? And what about a possible third, synthesizing option? Robert W. Greene discovers that the two apparently divergent intentions in question (metalinguistic vs. moralistic) often paradoxically coexist in French fiction. Also, no doubt because it is more consistently self-conscious (...) than that of any previous era, the fiction of twentieth-century France seems to illustrate this convergence with special brillance. From L'lmmoralist (1902) to L'Usage de la parole (1980) Greene explores combinations and permutations of moralistic analysis and metalinguistic commentary in a particular sequence of prose narrative. Along the way, he observes Gide, Proust, Malraux, Camus, Duras, and Sarraute, each in his or her own fashion, moving ceaselessly back and forth between soundings of the heart and diagnoses of the tongue. (shrink)

Michel Henry’s “Destruction ontologique” does not interpret itself. In the following interpretive essay, I will attempt to articulate its basic structure, to address its principal engagements, and, on this basis, to interpret its defining themes and positions. In the course of this attempt, I will comment also on the importance of this work in the context of Henry’s œuvre, and contemporary scholarship thereupon. One need not accept every assertion, or agree with every position, in this article to recognize its importance. (...) This importance is both greater, and different, than the reader may expect. (shrink)

The title already announces Henrich’s methodological reorientation, from the trajectory von Kant bis Hegel, to a constellation of post-Kantian theoretical philosophies comprehended as “three comparable and competing positions [those of Fichte, Schelling, and Hegel] that cannot be reduced to each other”. Chapters 1 through 3 provide the context for the later content of the work by introducing the theme of the formal interdependence of mind and world, of “internal experience” and our experience of a law-governed world external to us. This (...) co-relation Henrich understands as fundamental to both Kant’s own and post-Kantian philosophy, theoretical and practical. Henrich takes as basic “the insight that mental activity always implies a world within which such activity occurs.” This yields the claim that “the concept of mind as the subject of knowledge is not possible without the idea of a world that laws govern”. Henrich then adumbrates the ways in which Kant’s account of the structure and dynamics of this relation were taken to be either problematic or insufficient in theoretical philosophy between Kant and Hegel. (shrink)

This paper was originally a discussion proposal but data has been collected since June and we would like to share some results in this proceedings article. Our goal is to link the CSR literature with the social entrepreneurship literature by studying the growth of an international organization and discuss our methodologies and findings to date.

In this book, Arnold Green discusses the standards that define moral appraisal. Standards assume roles of conduct which can be imposed during socialization only within the traditional family. Otherwise, the basis of order, which is not collective but individual, is undermined by the extreme degree of disaffection we now face. All the panaceas offered, and in some cases enforced, by one intellectual minority or another, will inevitably have a destructive impact upon our communication with one another. Contents: Perception and (...) Ideology; Self and Family; Relativism and the Family Institution; Religion as Vital Force; Social Class and Prejudice. (shrink)

Two experiments using a realistic version of the selection task examined the relationship between participants' probability estimates of finding a counter example and their selections. Experiment 1 used everyday categories in the context of a scenario to determine whether or not the number of instances in a category affected the estimated probability of a counter-example. Experiment 2 modified the scenario in order to alter participants' estimates of finding a specific counter-example. Unlike Kirby 1994a, but consistent with his proposals, both studies (...) showed that probability estimates significantly predicted selection. Overall results point to the value of understanding selections in terms of their subjective expected utility. (shrink)

Hardman in press claims that the results of Green and Larking 1995 favour a mental rules theory account of performance in the selection task over a mental model theory account. This reply rebuts his claim.

Several researchers have suggested that a talented, quality workforce will become a more important source of competitive advantage for firms in the future. Drawing on social identity theory and signaling theory, the authors hypothesize that firms can use their corporate social performance (CSP) activities to attract job applicants. Specifically, signaling theory suggests that a firm’s CSP sends signals to prospective job applicants about what it would be like to work for a firm. Social identity theory suggests that job applicants have (...) higher self-images whenworking for socially responsive firms over their less responsive counterparts. The authors conducted an experiment in which they manipulated CSP and found that prospective job applicants are more likely to pursue jobs from socially responsible firms than from firms with poor social performance reputations. The implications of these findings for academicians and practitioners alike are discussed. (shrink)

The social impacts of computer technology are often glorified in public discourse, but there is growing concern about its actual effects on society. In this article, we ask: how does “consent” as an analytical framework make visible the social dynamics and power relations in the capture, extraction, and labor of data science knowledge production? We hypothesize that a form of boundary violation in data science workplaces—gender harassment—may correlate with the ways humans’ lived experiences are extracted to produce Big Data. The (...) concept of consent offers a useful way to draw comparisons between gender relations in data science and the means by which machines are trained to learn and reason. Inspired by how Big Tech leaders describe unsupervised machine learning, and the co-optation of “revolutionary” rhetoric they use to do so, we introduce a concept we call “techniques of invisibility.” Techniques of invisibility are the ways in which an extreme imbalance between exposure and opacity, demarcated along fault lines of power, are fabricated and maintained, closing down the possibility for bidirectional transparency in the production and applications of algorithms. Further, techniques of invisibility, which we group into two categories—epistemic injustice and the Brotherhood—include acts of subjection by powerful actors in data science designed to quell resistance to exploitative relations. These techniques may be useful in making further connections between epistemic violence, sexism, and surveillance, sussing out persistent boundary violations in data science to render the social in data science visible, and open to scrutiny and debate. (shrink)

Living organisms are the ultimate survivalists, having evolved phenotypes with unprecedented adaptability, ingenuity, resourcefulness, and versatility compared to human technology. To harness these properties, functional descriptions and design principles from all sources of biodiversity information must be collated − including the hundreds of thousands of possible survival features manifest in natural history museum collections, which represent 12% of total global biodiversity. This requires a consortium of expert biologists from a range of disciplines to convert the observations, data, and hypotheses into (...) the language of engineering. We hope to unite multidisciplinary biologists and natural history museum scientists to maximize the coverage of observations, descriptions, and hypotheses relating to adaptation and function across biodiversity, to make it technologically useful. This is to be achieved by developments in meta‐ taxonomic classification, phylogenetics, systematics, biological materials research, structure and morphological characterizations, and ecological data gathering from the collections − the aim being to identify and catalogue features essential for good biomimetic design. (shrink)

The three introductory questions posed by Hobson et al. point toward further investigations of cellular, circuit, and systems mechanisms involved in cognitive function that include the effect of CNS-state related modulatory systems on these mechanisms. [Hobson et al.].